박성규

박성규 (Song-Kyu Park)

Professor: Song-Kyu Park, Ph. D.

Laboratory of Molecular Pharmacology
Tel: +82-44-860-1614 (office), 82-44-860-1641 (lab)
Fax: +82-44-860-1606
E-mail: spark123@korea.ac.kr
Address: 2511 Sejong-ro, Sejong, South Korea 30019

Education

학력
Institution	Degree	Year	Field of Study
Seoul National University, South Korea	B.S.	1985	Pharmacy
KAIST, South Korea	M.S.	1987	Biological Science
The University of Iowa, IA, USA	Ph. D.	1995	Pharmacology

Positions and Employment

주요경력
Institution	Years	Position
Daewoong Pharmaceutical Co. Ltd.	1987-1991	Research Assistant
The University of Iowa	1996-1996	Postdoctoral Fellow
Harvard Medical School/BIDMC	1996-2001	Research Fellow
Korea Research Institute of Bioscience and Biotchnology	2001-2010	Principal Scientist
Korea University, College of Pharmacy	2011-2012	Associate Professor
Korea University, College of Pharmacy	2012-present	Professor

Research Interest

Identifying agents that modulate the function of cancer stem cells and elucidating their mechanism of actions
Our research is focused on elucidating the molecular mechanisms of agents that can induce the differentiation of cancer stem cells, which has been reported to take part in the development of recurring cancers. The monolayer layer culture of cancer stem cells, which has been established recently, is being used to identify agents inducing differentiation of cancer stem cells and the mechanisms of the actions of these agents are also being investigated.
In particular, we are highly interested in elucidating the role of some of the dopamine receptor antagonists in inducing the differentiation of cancer stem cells. In addition, we are trying to understand the structure-activity relationship between dopamine receptor antagonists and their differentiation inducing ability.
Drug repurposing study using stereoisomer drugs
Drug repurposing (also referred to as repositioning), the process of finding new uses of existing drugs, has been gaining a lot of attention in recent years. Many drugs are being used as racemates, which are mixtures of stereoisomers, in clinic. Each of stereoisomers may have similar activity on the target disease and only one type of stereoisomers may have activity. It has been reported that stereoisomers in a racemic mixture have totally different activities. We are trying to find new functions or activities of stereoisomers using a variety of cellular assay systems such as cancer cell liness, adipocyte cell lines, and immune cell lines.

Representative papers

Lee SI, Roney MSI, Park JH, Baek JY, Park J, Kim SK, Park SK. (Accepted) Dopamine receptor antagonists induce differentiation of PC-3 human prostate cancer cell-derived cancer stem cell-like cells. The prostate.
Roney MSI, Park SK (2018) Antipsychotic dopamine receptor antagonists, cancer, and cancer stem cells. Archives of Pharmacal Research, 41, 384-408.
Jeong YJ, Kang JS, Lee SI, So DM, Yun J, Baek JY, Kim SK, Lee K, Park SK (2016) Breast cancer cells evade paclitaxel-induced cell death by developing resistance to dasatinib. Oncology letters, 12, 2153-2158.
Kang MR*, Park SK*, Lee CW, Cho IJ, Jo YN, Yang JW, Kim JA, Yun J, Lee KH, Kwon HJ, Kim BW, Lee K, Kang JS, Kim HM (2012) Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells. Oncology reports, 27, 1407-1412. (*equally contributed)
Kang JS, Kim HM, Choi IY, Han SB, Yoon YD, Lee H, Park KH, Cho IJ, Lee CW, Lee K, Lee KH, Park SK (2010) DBM1285 suppresses tumor necrosis factor alpha production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. The Journal of pharmacology and experimental therapeutics, 334, 657-664.

Selected peer-reviewed articles (since 2011)

Jung HS, Lee SI, Kang SH, Wang JS, Yang EH, Jeon B, Myung J, Baek JY, Park SK (2017) Monoclonal antibodies against autocrine motility factor suppress gastric cancer. Oncology letters, 13, 4925-4932.
Yun J, Kim BG, Kang JS, Park SK, Lee K, Hyun DH, Kim HM, In MJ, Kim DC (2015) Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells. Journal of medicinal food, 18, 102-108.
Lee SI, Yun J, Baek JY, Jeong YJ, Kim JA, Kang JS, Park SH, Kim SK, Park SK (2015) NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3. Korean journal of physiology and pharmacology 19, 105-109.
Yu HE, Oh SJ, Ryu JK, Kang JS, Hong JT, Jung JK, Han SB, Seo SY, Kim YH, Park SK, Kim HM, Lee K (2014) Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats. Phytotherapy research 28, 568-578.
Shin JA, Han G, Park SK, Lee K, Kim HJ, Cho SD, Kim HM (2014) The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells. Oral diseases, 20, 482-489.
Ryu CS, Oh SJ, Oh JM, Lee SY, Kwak HC, Yun KU, Lee JY, Park SK, Kim BH, Ma JY, Kim SK (2014) Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats. Archives of pharmacal research, 37, 1345-1353.
Yun KU, Ryu CS, Lee JY, Noh JR, Lee CH, Lee HS, Kang JS, Park SK, Kim BH, Kim SK (2013) Hepatic metabolism of sulfur amino acids in db/db mice. Food and chemical toxicology 53, 180-186.
Yang JS, Song D, Ko WJ, Kim B, Kim BK, Park SK, Won M, Lee K, Lee K, Kim HM, Han G (2013) Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: part II. European journal of medicinal chemistry, 63, 621-628.
Song D, Yang JS, Kim SJ, Kim BK, Park SK, Won M, Lee K, Kim HM, Choi KY, Lee K, Han G (2013) Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents. Bioorganic & medicinal chemistry, 21, 788-794.
Shin JH, Lee CW, Oh SJ, Yun J, Lee K, Park SK, Kim HM, Han SB, Kim Y, Kim HC, Kang JS (2013) Protective effect of silymarin against ethanol-induced gastritis in rats: role of sulfhydryls, nitric oxide and gastric sensory afferents. Food and chemical toxicology 55, 353-357.
Lee SY, Lee JY, Kang W, Kwon KI, Park SK, Oh SJ, Ma JY, Kim SK (2013) Cytochrome P450-mediated herb-drug interaction potential of Galgeun-tang. Food and chemical toxicology 51, 343-349.
Jung YS, Yun KU, Ryu CS, Oh JM, Kwak HC, Lee JY, Park SK, Kim BH, Oh SJ, Kim SK (2013) Alterations in hepatic metabolism of sulfur amino acids in non-obese type-2 diabetic Goto-Kakizaki rats. Chemico-biological interactions, 204, 80-87.
Choi ES, Han G, Park SK, Lee K, Kim HJ, Cho SD, Kim HM (2013) A248, a novel synthetic HDAC inhibitor, induces apoptosis through the inhibition of specificity protein 1 and its downstream proteins in human prostate cancer cells. Molecular medicine reports, 8, 195-200.
Cho M, Choi E, Yang JS, Lee C, Seo JJ, Kim BS, Oh SJ, Kim HM, Lee K, Park SK, Kwon HJ, Han G (2013) Discovery of pyridone-based histone deacetylase inhibitors: approaches for metabolic stability. ChemMedChem, 8, 272-279.
Cho IJ, Lee CW, Lee MY, Kang MR, Yun J, Oh SJ, Han SB, Lee K, Park SK, Kim HM, Jung SH, Kang JS (2013) Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents. International immunopharmacology, 16, 457-460.
Park KH, Yoon YD, Han SB, Oh SJ, Yun J, Lee CW, Lee K, Park SK, Kim HM, Kang JS (2012) Artemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: implications on signal transducer and activator of transcription-1 signaling and nitric oxide production. International immunopharmacology, 14, 580-584.
Lee C, Choi E, Cho M, Lee B, Oh SJ, Park SK, Lee K, Kim HM, Han G (2012) Structure and property based design, synthesis and biological evaluation of gamma-lactam based HDAC inhibitors: part II. Bioorganic & medicinal chemistry letters, 22, 4189-4192.
Kang MR, Lee CW, Yun J, Oh SJ, Park SK, Lee K, Kim HM, Han SB, Kim HC, Kang JS (2012) Methanolic Extract Isolated from Root of Lycoris aurea Inhibits Cancer Cell Growth and Endothelial Cell Tube Formation In Vitro. Toxicological research, 28, 33-38.
Kang MR, Kang JS, Yang JW, Kim BG, Kim JA, Jo YN, Lee K, Lee CW, Lee KH, Yun J, Kim HM, Han G, Kang JS, Park SK (2012) Gene expression profiling of KBH-A42, a novel histone deacetylase inhibitor, in human leukemia and bladder cancer cell lines. Oncology letters, 3, 113-118.
Choi E, Lee C, Cho M, Seo JJ, Yang JS, Oh SJ, Lee K, Park SK, Kim HM, Kwon HJ, Han G (2012) Property-based optimization of hydroxamate-based gamma-lactam HDAC inhibitors to improve their metabolic stability and pharmacokinetic profiles. Journal of medicinal chemistry, 55, 10766-10770.
Yang JS, Song D, Lee B, Ko WJ, Park SK, Won M, Lee K, Kim HM, Han G (2011) Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: part I. European journal of medicinal chemistry, 46, 2861-2866.
Oh SJ, Lee K, Ryu J, Yu HE, Han G, Park SK, Kang JS, Kim HM, Kim YC (2011) Evaluation of the pharmacokinetics and metabolism of a novel histone deacetylase inhibitor, KBH-A40, in rats. Xenobiotica; the fate of foreign compounds in biological systems, 41, 155-163.
Lee SJ, Kang HY, Kim SY, Chung JH, Oh SJ, Ryu JS, Kim SB, Kang JS, Park SK, Kim HM, Kim MH, Moon DH (2011) Early assessment of tumor response to JAC106, an anti-tubulin agent, by 3'-deoxy-3'-[(1)(8)F]fluorothymidine in preclinical tumor models. European journal of nuclear medicine and molecular imaging, 38, 1436-1448.
Kim TD, Lee SU, Yun S, Sun HN, Lee SH, Kim JW, Kim HM, Park SK, Lee CW, Yoon SR, Greenberg PD, Choi I (2011) Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity. Blood, 118, 5476-5486.
Kim BK, Kim HM, Chung KS, Kim DM, Park SK, Song A, Won KJ, Lee K, Oh YK, Lee K, Song KB, Simon JA, Han G, Won M (2011) Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618. Carcinogenesis, 32, 254-261.
Kim BK, Kim DM, Chung KS, Park SK, Choi SJ, Song A, Lee K, Lee CW, Song KB, Han G, Simon J, Kim HM, Won M (2011) NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells. Investigational new drugs, 29, 853-860.
Kang MR, Kim HM, Kang JS, Lee K, Lee SD, Hyun DH, In MJ, Park SK, Kim DC (2011) Lipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells. Plant foods for human nutrition, 66, 101-106.
Kang JS, Lee WK, Yoon WK, Kim N, Park SK, Park HK, Ly SY, Han SB, Yun J, Lee CW, Lee K, Lee KH, Park SK, Kim HM (2011) A combination of grape extract, green tea extract and L-carnitine improves high-fat diet-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease in mice. Phytotherapy research 25, 1789-1795.
Kang JS, Lee WK, Lee CW, Yoon WK, Kim N, Park SK, Lee HS, Park HK, Han SB, Yun J, Lee K, Lee KH, Park SK, Kim HM (2011) Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and L-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases. Food and chemical toxicology 49, 2453-2458.
Choi E, Lee C, Park JE, Seo JJ, Cho M, Kang JS, Kim HM, Park SK, Lee K, Han G (2011) Structure and property based design, synthesis and biological evaluation of gamma-lactam based HDAC inhibitors. Bioorganic & medicinal chemistry letters, 21, 1218-1221.