변영주

변영주 (Youngjoo Byun)

Professor: Youngjoo Byun, Ph. D.

Laboratory of Medicinal Chemistry/Molecular Imaging
Homepage: http://medchem.korea.ac.kr
Tel: +82-44-860-1619 (office), +82-44-860-1644 (lab)
Fax: +82-44-860-1606
E-mail: yjbyun1@korea.ac.kr
Address: 2511 Sejong-ro, Sejong City, South Korea 30019

Education

학력
Institution	Degree	Year	Field of Study
Seoul National University, South Korea	B.S.	1994	Pharmacy
Seoul National University, South Korea	M.S.	1996	Medicinal Chemistry
The Ohio State University, Columbus, OH, USA	Ph. D	2006	Medicinal Chemistry

Positions and Employment

주요경력
Institution	Years	Position
AmorePacific Corp.	1996-2001	Scientist/Senior Scientist
School of Medicine, Johns Hopkins Univ.	2006-2007	Postdoctoral Fellow
School of Medicine, Johns Hopkins Univ.	2007-2009	Research Associate
School of Medicine, Johns Hopkins Univ.	2009-2011	Instructor
College of Pharmacy, Korea Univ.	2011-2013	Assistant Professor
College of Pharmacy, Korea Univ.	2013-2017	Associate Professor
College of Pharmacy, Korea Univ.	2017-present	Professor

Research Interest

Design, identification and discovery of novel molecular imaging probes for the diagnosis of prostate cancer and neurological diseases. Prostate cancer target proteins: Prostate-specific membrane antigen (PSMA) and hepsin
Design and Synthesis of novel inhibitors to modulate allergic immune responses targeting cytokines including interleukin-33, TSLP, and IL-25.
Structure-activity relationship studies of gingerol-derived biofilm inhibitors.

Selected Publications (since 2015)

H. S. Kim; S. H. Lee; Y. Byun*; H. D. Park*, 6-gingerol reduces pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition, Scientific Reports, 2015, 5, 8656
S. Park; H. S. Kim; K. Ok; Y. Kim; H. D. Park*; Y. Byun* Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors, Bioorganic & Medicinal Chemistry Letters, 2015, 25(15), 2913-2917
M Subedi; J Chen; E Kang; KI Kim; Y Byun* Facile Synthesis of 2-(4-Hydroxybiphenyl-3-yl)-1 Hindoles from Anilines and 5′-Bromo-2′-hydroxyacetophenone, Synthetic Communications, 2015, 45(14), 1704-1709
S Youn, K Kim, J Ptacek, K Ok, Z Novakova, Y Kim, J Koo, C Barinka*, Y Byun*, Carboranecontaining urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization, Bioorganic & Medicinal Chemistry Letters, 2015, 25(22), 5232-5236
H Kwon, Y Kim, K Park, S Choi, S Son*, Y Byun*, Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors, Bioorganic & Medicinal Chemistry Letters, 2016, 26(2), 310-314
HS Kim, E Cha, YH Kim, YH Jeon, BH Olson, Y Byun*, HD Park*, Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels, Scientific Reports, 2016, 6, 25318
M Subedi, I Minn, J Chen, YH Kim, K Ok, YW Jung, MG Pomper, Y Byun*, Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands, European Journal of Medicinal Chemistry, 2016, 118, 208-218
B Park, N Lee, Y Kim, Y Jae, S Choi, N Kang, Y Hong, K Ok, J Cho, Y Jeon, E Lee, Y Byun*, J Koo*, Analogues of dehydroacetic acid as selective and potent agonists of an ectopic edorant receptor through a combination of hydrophilic and hydrophobic interactions, ChemMedChem, 2017, 12, 477-482
H Kwon, J Han, KY Lee, SH Son*, Y Byun*, Recent advances of hepsin-targeted inhibitors, Current Medicinal Chemistry, 2017, 24, 2294-2311
TS Kim, SY Ham, B Park, Y Byun*, HD Park*, Lauroyl arginate ethyl blocks the iron signals necessary for Pseudomonas aeruginosa biofilm development, Frontiers in Microbiology, 2017, 8, 970
S Park, Y Park, SH Son, K Lee, YW Jung, KY Lee, YH Jeon*, Y Byun*, Synthesis and biological evaluation of peptide-derived TSLP inhibitors, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4710-4713
H Choi. SY Ham, E Cha, HS Kim, JK Bang, SH Son, HD Park*, Y Byun*, Structure-activity relationships of 6- and 8-gingerol analogs as anti-biofilm agents, Journal of Medicinal Chemistry, 2017, 60(23), 9821-9837
H Kim, K Kim, S-H Son, JY Choi, K-H Lee, B-T Kim, Y Byun*, YS Choe*, 18F-Labeled BODIPY Dye: A Potential Prosthetic Group for Brain Hybrid PET/Optical Imaging Agents, ACS chemical neuroscience, 2018, in press
Y BYUN*, KY Lee, K Lee, YH Jeon, YW Jung, Peptide derivative for regulating thymic stromal lymphoid protein-mediated signaling and pharmaceutical composition for preventing and treating allergy and asthma diseases comprising same, US patent granted, US10059743B2, 2018-08-28
Y BYUN*, CH Lee, 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives, US patent granted, US10155753B2, 2018-12-18