-
오수환
(Soohwan Oh)
-
Professor: Soo An Choi, Ph. D.
- Molecular Biology/Transcriptomics
- Tel: 044-860-1621 (office) 044-860-1640 (Lab)
- Fax: 044-860-1606
- email: soohwanoh@korea.ac.kr
- Address: 2511 Sejong-ro, Sejong South Korea 30019
학력
| 학교 | 학위 | 년도 | 전공 |
|---|---|---|---|
| Korea University | B.S | 2007 | Life Science |
| Korea University | M.S | 2009 | Molecular and Cellular Bioloby |
| University of California San Diego | 박사 | 2018 | Biological Science |
주요경력
| 근무기관명 | 년도 | 직위 |
|---|---|---|
| University of Southern California | 2009-2011 | Lab Scientist |
| University of California San Diego | 2018-2022 | Postdoctoral Fellow |
| College of Pharmacy, Korea Univ. | 2022-present | Assistant professor |
Research interest
- RNA as a novel therapeutic approach.
- Transcription mechanism studies by analyzing NGS data of Transcriptome and Genome sequence.
- Research of pathological/pharmacological mechanisms in disease through NGS methods.
- Developing de novo NGS methods for research and diagnostics.
발표논문 (Publication)
First/co-first/co-corresponding author articles
- OH, S., SHAO, J., MITRA, J., XIONG, F., D'ANTONIO, M., WANG, R., GARCIA-BASSETS, I., MA, Q., ZHU, X., LEE, J. H., NAIR, S. J., YANG, F., OHGI, K., FRAZER, K. A., ZHANG, Z. D., LI, W. & ROSENFELD, M. G.. Enhancer Release and Retargeting (ERR) Activates Disease Susceptibility Genes. Nature, 595, 735–740 (2021).https://doi.org/10.1038/s41586-021-03577-1 (Impact Factor: 42.78)
- LI, W*., HU, Y*., OH, S*., MA, Q., MERKURJEV, D., SONG, X., ZHOU, X., LIU, Z., TANASA, B., HE, X., CHEN, A. Y., OHGI, K., ZHANG, J., LIU, W. & ROSENFELD, M. G. 2015. Condensin I and II Complexes License Full Estrogen Receptor alpha- Dependent Enhancer Activation. Mol Cell., 59, 188-202. (* denotes co-first author, Impact Factor: 15.584)
- ZHAO, Z*., OH, S*., LI, D., NI, D., PIROOZ, S. D., LEE, J. H., YANG, S., LEE, J. Y., GHOZALLI, I., COSTANZO, V., STARK, J. M. & LIANG, C. 2012. A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell., 22, 1001-16. (* denotes co-first author, Impact Factor: 10.092)
- PIROOZ, S. D., LEE, J. H., ZHAO, Z., NI, D., OH, S+. & LIANG, C+. 2011. Measurement of gammaHV68 infection in mice. J Vis Exp., (57). 3472. (+denotes co-corresponding author, Impact Factor: 1.2)
- OH, S*., XIAOFEI, E*., NI, D., PIROOZ, S. D., LEE, J. Y., LEE, D., ZHAO, Z., LEE, S., LEE, H., KU, B., KOWALIK, T., MARTIN, S. E., OH, B. H., JUNG, J. U. & LIANG, C. 2011b. Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis. Cell Death Differ., 18, 452-64. (* denotes co-first author, Impact Factor: 10.717)
- OH, S., PIROOZ, S. D., NI, D., ZHAO, Z. & LIANG, C. 2011a. Anti-autophagic Bcl-2: Not just an innocent bystander. (punctum), Autophagy., 7, 231-2. (Impact Factor: 9.77)
- OH, S., E, X., HWANG, S. & LIANG, C. 2010. Autophagy evasion in herpesviral latency. (punctum), Autophagy., 6, 151-2. (Impact Factor: 9.77)
- E, X*., HWANG, S*., OH, S*., LEE, J. S., JEONG, J. H., GWACK, Y., KOWALIK, T. F., SUN, R., JUNG, J. U. & LIANG, C. 2009. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog., 5, e1000609. (* denotes co-first author, Impact Factor: 6.218)
Co-author articles
- PARK, A., OH, S., JUNG, K. L., CHOI, U. Y., LEE, H. R., ROSENFELD, M. G. & JUNG, J. U. 2020. Global epigenomic analysis of KSHV-infected primary effusion lymphoma identifies functional MYC superenhancers and enhancer RNAs. Proc Natl Acad Sci USA., 117, 21618-21627. (Impact Factor: 9.412)
- MA, Q., YANG, F., MACKINTOSH, C., JAYANI, R. S., OH, S., JIN, C., NAIR, S. J., MERKURJEV, D., MA, W., ALLEN, S., WANG, D., ALMENAR-QUERALT, A. & GARCIA-BASSETS, I. 2020. Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells. Cell Rep., 31, 107532. (Impact Factor: 8.109)
- NAIR, S. J., YANG, L., MELUZZI, D., OH, S., YANG, F., FRIEDMAN, M. J., WANG, S., SUTER, T., ALSHAREEDAH, I., GAMLIEL, A., MA, Q., ZHANG, J., HU, Y., TAN, Y., OHGI, K. A., JAYANI, R. S., BANERJEE, P. R., AGGARWAL, A. K. & ROSENFELD, M. G. 2019. Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly. Nat Struct Mol Biol., 26, 193-203. (Impact Factor: 11.98)
- TAN, Y., JIN, C., MA, W., HU, Y., TANASA, B., OH, S., GAMLIEL, A., MA, Q., YAO, L., ZHANG, J., OHGI, K., LIU, W., AGGARWAL, A. K. & ROSENFELD, M. G. 2018. Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program. Mol Cell., 71, 526-539.e8. (Impact Factor: 15.584)
- YI, E., OH, J., GIAO, N. Q., OH, S. & PARK, S. H. 2017. Enhanced production of enveloped viruses in BST-2-deficient cell lines. Biotechnol Bioeng., 114, 2289-2297. (Impact Factor: 4.002)
- HE, S., ZHAO, Z., YANG, Y., O'CONNELL, D., ZHANG, X., OH, S., MA, B., LEE, J. H., ZHANG, T., VARGHESE, B., YIP, J., DOLATSHAHI PIROOZ, S., LI, M., ZHANG, Y., LI, G. M., ELLEN MARTIN, S., MACHIDA, K. & LIANG, C. 2015. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun., 6:7839. (Impact Factor: 12.121)
- TELESE, F., MA, Q., PEREZ, P., NOTANI, D., OH, S., LI, W., COMOLETTI, D., OHGI, K., TAYLOR, H. & ROSENFELD, M. 2015a. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron, 86, 696-710. (Impact Factor: 14.403)
- LEE, J. Y., SKON, C. N., LEE, Y. J., OH, S., TAYLOR, J. J., MALHOTRA, D., JENKINS, M. K., ROSENFELD, M. G., HOGQUIST, K. A. & JAMESON, S. C. 2015. The transcription factor KLF2 restrains CD4(+) T follicular helper cell differentiation. Immunity., 42, 252-264. (Impact Factor: 21.522)
- LIU, Z., MERKURJEV, D., YANG, F., LI, W., OH, S., FRIEDMAN, M. J., SONG, X., ZHANG, F., MA, Q., OHGI, K. A., KRONES, A. & ROSENFELD, M. G. 2014. Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell., 159, 358-73. (Impact Factor: 36.216)
- JIN, C., YANG, L., XIE, M., LIN, C., MERKURJEV, D., YANG, J. C., TANASA, B., OH, S., ZHANG, J., OHGI, K. A., ZHOU, H., LI, W., EVANS, C. P., DING, S. & ROSENFELD, M. G. 2014. Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens. Proc Natl Acad Sci USA., 111, 9235-40. (Impact Factor: 9.412)
- Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O’Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci USA., 2014 Feb 18;111(7):2716-21. (Impact Factor: 9.412)
- HE, S., NI, D., MA, B., LEE, J. H., ZHANG, T., GHOZALLI, I., PIROOZ, S. D., ZHAO, Z., BHARATHAM, N., LI, B., OH, S., LEE, W. H., TAKAHASHI, Y., WANG, H. G., MINASSIAN, A., FENG, P., DERETIC, V., PEPPERKOK, R., TAGAYA, M., YOON, H. S. & LIANG, C. 2013. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat Cell Biol., 15, 1206-1219. (Impact Factor: 20.042)
- LI, W., NOTANI, D., MA, Q., TANASA, B., NUNEZ, E., CHEN, A. Y., MERKURJEV, D., ZHANG, J., OHGI, K., SONG, X., OH, S., KIM, H. S., GLASS, C. K. & ROSENFELD, M. G. 2013. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature., 498, 516-20. doi: 10.1038/nature12210. (Impact Factor: 42.778)
- JEONG, J. H., BHATIA, A., TOTH, Z., OH, S., INN, K. S., LIAO, C. P., ROY-BURMAN, P., MELAMED, J., COETZEE, G. A. & JUNG, J. U. 2011. TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth. PLoS One., 6, e16205. (Impact Factor: 2.74)
- LEE, H., HONG, C., SHIN, J., OH, S., JUNG, S., PARK, Y. K., HONG, S., LEE, G. R. & PARK, S. H. 2009. The presence of CD8+ invariant NKT cells in mice. Exp Mol Med., 41, 866-72. (Impact Factor: 5.063) A complete list and access to summaries can be found at My NCBI bibliography: