전영호

전영호 (Young-Ho Jeon)

Professor: Young-Ho Jeon, Ph. D.

Laboratory of Biochemistry/Structural Biology
Tel: +82-44-860-1615 (office), 82-44-860-1643 (lab)
Fax: +82-44-860-1606
E-mail: yhjeon@korea.ac.kr
Address: 2511 Sejong-ro, Sejong Special Self-Governing City, South Korea 30019

Education

학력
Institution	Degree	Year	Field of Study
Seoul National University, South Korea	B.S.	1985	Pharmacy
Seoul National University, South Korea	M.S.	1987	Physical Pharmacy
Osaka University, Japan	Ph.D.	1996	Biochemistry

Biochemistry

주요경력
Institution	Years	Position
LG Biotech Research Institute	1988-1991	Research Scientist
Ciba-Geigy, IRL	1996-1997	Postdoctoral Fellow
LG Biotech Research Institute	1997-2000	Senior Researcher
CrystalGenomics, Inc.	2000-2005	Principal Researcher
Korea Basic Science Institute	2005-2011	Principal Researcher
Korea University, College of Pharmacy	2011-2012	Associate Professor
Korea University, College of Pharmacy	2012-present	Professor

Research Interest

Structural biology for protein synthesis machinery
CD4 T helper type 2 (Th2) cells play a central role in developing allergic diseases such as asthma and atopic dermatitis. Although cytokines including TSLP have been suggested to influence the development of allergic diseases, it is still poorly understood how Th2 cells are formed and maintained. Therefore, we aim to study the molecular mechanisms of the development and function of Th2 cells by determining the 3D structure of cyotkine-receptor interactions. We also propose to explore proprietary technologies to modulate allergic responses by developing new lead compounds through the inhibition of cytokine receptor interactions. This study has great potential to provide basic knowledge and technology for novel approaches to "cure" allergic diseases.
Structural studies of the cytokines and their receptors in allergy signaling for the elucidation of pathological mechanism in allergic diseases and their application for therapeutic intervention.
Structural biology for protein synthesis machinery
Aminoacyl-tRNA synthetase (AARS) is an enzyme that catalyzes the esterification of a specific amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA. AARS form multi-synthetase complex (MSC) with cofactors such as p43, p38, and p18. Recently, there are substantial reports regarding that AARS are related to many disease including cancer, neurological disease, and autoimmune diseases. In this project, using a technology platform based on structural biology (X-ray crystallography and NMR spectroscopy), we are studying multi-synthetase complex of AARS and their interactions in the cell signaling.

Representative papers

Kim K, Khayrutdinov BI, Lee CK, Cheong HK, Kang SW, Park H, Lee S, Kim YG, Jee J, Rich A*, Kim KK*, Jeon YH* (2011) Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs. Proc Natl Acad Sci U S A. 108(17):6921-6
Sun D, Lee G, Lee JH, Kim HY, Rhee HW, Park SY, Kim KJ, Kim Y, Kim BY, Hong JI, Park C, Choy HE, Kim JH, Jeon YH*, Chung J*. (2010) A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat Struct Mol Biol. 17(10): 1188-94 (* corresponding authors)
Maslennikov I, Klammt C, Hwang E, Kefala G, Okamura M, Esquivies L, Mörs K, Glaubitz C, Kwiatkowski W, Jeon YH*, Choe S*. (2010) Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysis. Proc Natl Acad Sci U S A. 107(24):10902-7 (* corresponding authors)
Sung BJ*, Hwang KY*, Jeon YH*, Lee JI*, Heo YS, Kim JH, Moon J, Yoon JM, Hyun YL, Kim E,Eum SJ, Park SY, Lee JO, Lee TG, Ro S & Cho JM (2003) Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules, Nature 425, 98-102 (SCI factor, 30.4) (*These authors contributed equally to this work)
Jeon YH, Negishi T, Shirakawa M, Yamazaki T, Fujita N, Ishihama A, Kyogoku Y. (1995) Solution structure of the activator contact domain of the RNA polymerase alpha subunit. Science. 1995 Dec 1;270(5241):1495-7.

Selected peer-reviewed articles (since 2014)

Shin H, Park Y, Jeon YH, Yan XT, Lee KY. (2018) Identification of Polygonum orientale constituents using high-performance liquid chromatography high-resolution tandem mass spectrometry. Biosci Biotechnol Biochem. 82(1):15-21.
Mushtaq AU, Lee Y, Hwang E, Bang JK, Hong E, Byun Y, Song JJ, Jeon YH* (2018) Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA. Biochem Biophys Res Commun. 495(1):145-150.
Yeo KJ, Jee JG, Hwang E, Kim EH, Jeon YH*, Cheong HK*. (2017) Interaction between human angiogenin and the p53 TAD2 domain and its implication for inhibitor discovery. FEBS Lett. 591(23):3916-3925.
Kwon HI, Kim S, Oh MH, Na SH, Kim YJ, Jeon YH, Lee JC. (2017) Outer membrane protein A contributes to antimicrobial resistance of Acinetobacter baumannii through the OmpA-like domain. J Antimicrob Chemother. 72(11):3012-3015.
Park S, Park Y, Son SH, Lee K, Jung YW, Lee KY, Jeon YH*, Byun Y* (2017) Synthesis and biological evaluation of peptide-derived TSLP inhibitors. Bioorg Med Chem Lett 27(20):4710-4713.
Mushtaq AU, Park JS, Bae SH, Kim HY, Yeo KJ, Hwang E, Lee KY, Jee JG, Cheong HK*, Jeon YH*. (2017) Ligand-Mediated Folding of the OmpA Periplasmic Domain from Acinetobacter baumannii. Biophys J. 112(10):2089-2098.
Hwang E, Cheong HK, Kim SY, Kwon O, Blain KY, Choe S, Yeo KJ, Jung YW, Jeon YH*, Cheong C*. (2017) Crystal structure of the EnvZ periplasmic domain with CHAPS. FEBS Lett. 591(10):1419-1428.
Oh MH, Lee HJ, Jo SH, Park BB, Park SB, Kim EY, Zhou Y, Jeon YH, Lee K (2017) Development of Cassette PAMPA for Permeability Screening. Biol Pharm Bull. 40(4):419-424.
Jha R, Cho HY, Mushtaq AU, Lee K, Kim DG, Kim S, Jeon YH* (2017) Data on optimization of expression and purification of AIMP2-DX2 protein in Escherichia coli. Data Brief. 11:533-536.
Park BB, Lee N, Kim Y, Jae Y, Choi S, Kang N, Hong YR, Ok K, Cho J, Jeon YH, Lee EH, Byun Y, Koo J (2017) Analogues of Dehydroacetic Acid as Selective and Potent Agonists of an Ectopic Odorant Receptor through a Combination of Hydrophilic and Hydrophobic Interactions. ChemMedChem. 12(7):477-482.
Jha R, Cho HY, Mushtaq AU, Lee K, Kim DG, Kim S, Jeon YH* (2017) Purification and biophysical characterization of the AIMP2-DX2 protein. Protein Expr Purif. 132:131-137
Ahn M, Gunasekaran P, Rajasekaran G, Kim EY, Lee SJ, Bang G, Cho K, Hyun JK, Lee HJ, Jeon YH, Kim NH, Ryu EK, Shin SY, Bang JK. (2017) Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity. Eur J Med Chem. 125:551-564
Yeo KJ, Lee WC, Lee S, Hwang E, Park J-S, Choi I-C, Kim SI, Lee JC, Jeon YH, Cheong C, Kim H-Y (2017) D-Stereoisomer preference of the OmpA-like domain of Pal inpeptidoglycan of Acinetobacter baumannii, Process Biochemistry, in press
Shin H, Park Y, Choi JH, Jeon YH, Byun Y, Sung SH, Lee KY. (2017) Structure elucidation of a new triterpene from Rhus trichocarpa roots. Magn Reson Chem. 55(8):763-766.
Cho HY, Kim S, Jeon YH* (2017) Fragment-based methods for the discovery of inhibitors modulating lysyl-tRNA synthetase and laminin receptor interaction. Methods. 113:56-63.
Sim DW, Choi JW, Kim JH, Ryu KS, Kim M, Yu HW, Jo KS, Kim EH, Seo MD, Jeon YH, Lee BJ, Kim YP, Won HS. (2016) C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution. FEBS Lett. 2017 Feb 28. doi: 10.1002/1873-3468.12613. [Epub ahead of print]
Yeo KJ, Park JW, Kim EH, Jeon YH, Hwang KY, Cheong HK. (2016) Characterization of the sensor domain of QseE histidine kinase from Escherichia coli. Protein Expr Purif. 126:122-6.
Oh KE, Shin H, Jeon YH, Jo YH, Lee MK, Lee KS, Park B, Lee KY. (2016) Optimization of pancreatic lipase inhibitory and antioxidant activities of Ilex paraguariensis by using response surface methodology. Arch Pharm Res. 39(7):946-52
Jeon YH, Lee JW, Kim S (2016) Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis. Biochim Biophys Acta. 1864(12):1707-1713
Mushtaq AU, Cho HY, Byun Y and Jeon YH* (2016) Backbone assignment of the anticodon binding domain of human Glycyl-tRNA synthetase. J. Kor Mag Res Soc 20: 50-55
Kim HS, Cha E, Kim Y, Jeon YH, Olson BH, Byun Y, Park HD (2016) Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels. Scientific Reports 6: 25318.
Kim YK, Cho SH, Mushtaq A, Cho H, Jung YW, Byun Y, Jeon YH* (2016) Discovery of an Interleukin 33 Inhibitor by Molecular Docking Simulation and NMR Analysis. Bull Kor Chem Soc. 37(2): 117-118
Lee KY, Choi JH, Kim HW, Yan XT, Shin H, Jeon YH, Sung SH. (2016) New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells. Planta Med. 82(7):645-9
Hwang J, Nguyen LT, Jeon YH, Lee CY, Kim MH. (2015) Crystal structure of fully oxidized human thioredoxin. Biochem Biophys Res Commun. 467(2):218-22.
Park YH, Shi YP, Liang B, Medriano CA, Jeon YH, Torres E, Uppal K, Slutsker L, Jones DP. (2015) High-resolution metabolomics to discover potential parasite-specific biomarkers in a Plasmodium falciparum erythrocytic stage culture system. Malar J. 14:122.
Fu Y, Kim Y, Jin KS, Kim HS, Kim JH, Wang D, Park M, Jo CH, Kwon NH, Kim D, Kim MH, Jeon YH, Hwang KY, Kim S, Cho Y. (2014) Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation. Proc Natl Acad Sci U S A. 111(42):15084-9.
Yeo KJ, Hwang E, Min KM, Jee JG, Lee CK, Hwang KY, Jeon YH, Chang SI, Cheong HK. (2014) The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex. Chem Commun (Camb). 50(85):12966-9.
Kim HG, Yeon SM, Kim KH, Kim H, Park JI, Kang HJ, Cha EJ, Park HD, Kang HJ, Park TW, Jeon YH, Park YI, Chang KT, Jung YW. (2015) Estrogenic endocrine-disrupting chemicals modulate the production of inflammatory mediators and cell viability of lipopolysaccharide-stimulated macrophages. Inflammation. 38(2):595-605.
Jeong KW, Kang DI, Lee E, Shin A, Jin B, Park YG, Lee CK, Kim EH, Jeon YH, Kim EE, Kim Y. (2014) Structure and Backbone Dynamics of vanadate-bound PRL-3: Comparison of 15N NMR Relaxation Profiles of free and vanadate-bound PRL-3. Biochemistry. 53(29):4814-25.