이기용

이기용 (Ki-Yong Lee)

Professor: Ki-Yong Lee, Ph. D.

Laboratory of Pharmacognosy
Tel: +82-44-860-1623(office)
Fax: +82-44-860-1606
E-mail: kylee11@korea.ac.kr
Address: 2511 Sejong-ro, Sejong South Korea 30019

Education

학력
Institution	Degree	Year	Field of Study
Seoul National University, South Korea	B.S.	1999	Pharmacy
Seoul National University, South Korea	M.S.	2001	Pharmacognosy
Seoul National University, South Korea	Ph. D.	2007	Pharmacognosy

Positions and Employment

주요경력
Institution	Years	Position
College of Pharmacy, Seoul National University	2007-2009	Postdoctoral Research Fellow
Institute for Life Science Elcom Science Co.Ltd.,	2007-2009	Principal Research Scientist
Department of Neurology and Ophthalmology, Michigan State University	2009-2011	Visiting Research Associate
College of Pharmacy, Seoul National University.	2012-2013	Research Professor
College of Pharmacy, Korea University	2013-present	Professor

Research Interest

Discovery of neuroprotective and cognitive-enhancing natural products
Analysis of quantitative/qualitative relationship between chemical characteristics and bioactivity using LC-QTOF MS/MS
Phytochemical analysis of herbs and herbal medicines

Selected peer-reviewed articles (since 2015)

Jangmi Yun, Ki Yong Lee*, Byoungduck Park*. Neotuberostemonine inhibits osteoclastogenesis via blockade of NF-κB pathway. Biochimie 157: 81-91 (2019) (*co-corresponding author)
Joon Hyuk Hou, Hyunjung Shin, Kyoung Hwa Jang, Chae Kyu Park, Bonsuk Koo, Hyeji Shin, Soon Hong Yuk,* and KiYongLee*.Anti-acnepropertiesofhydrophobicfractionofredginseng(Panax ginseng C.A. Meyer) and its active components. Phytotherapy Research (in press) (*co-corresponding author)
Buyun Kim, Ki Yong Lee*, Byoungduck Park*. Icariin abrogates osteoclast formation through the regulation of the RANKL-mediated TRAF6/NF-κB/ERK signaling pathway in Raw 264.7 cells. Phytomedicine 51:181-190 (2018) (*co-corresponding author)
Jae Young Jang, Hyeji Shin, Jae-Woong Lim, Jong Hoon Ahn, Yang Hee Jo, KiYongLee,Bang Yeon Hwang, Sung-Ju Jung, So Young Kang, Mi Kyeong Lee*. Comparison of antibacterial activity and phenolic constituents of bark, lignum, leaves and fruit of Rhus verniciflua.PLoS One. 13(7): e0200257 (2018)
Sangmin Park, Hyeji Shin, Yeeun Park, Ilgyu Choi, Byoungduck Park*, Ki Yong Lee* Characterization of inhibitory constituents of NO production from Catalpa ovata using LC-MS coupled with a cell-based assay. Bioorganic Chemistry 80:57–63 (2018) (*co-corresponding author)
Jong Hoon Ahn, Yang Hee Jo, Seon Beom Kim, Ayman Turk, Kyung-Eon Oh, Bang Yeon Hwang, Ki Yong Lee*, Mi Kyeong Lee* Identification of antioxidant constituents of the aerial part of Plantago asiatica using LC–MS/MS coupled DPPH assay. Phytochemistry Letters 26:20-24 (2018) (*co-corresponding author)
Hyeji Shin, Yeeun Park, Young Ho Jeon, Xi-Tao Yan, and Ki Yong Lee. Identification of Polygonum orientale constituents using high-performance liquid chromatography high-resolution tandem mass spectrometry. Bioscience, Biotechnology, and Biochemistry 82(1):15-21 (2018)
Hyo Hee Yang, Kyung-Eon Oh,Yang Hee Jo, Jong Hoon Ahn, Qing Liu, Ayman Turk, Jae Young Jang, Bang Yeon Hwang, Ki Yong Lee*, Mi Kyeong Lee.* Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay. Bioorganic & Medicinal Chemistry 26(2):509-515 (2018)(*co-corresponding author)
Hyeji Shin, Carl Angelo Medriano, Byoungduck Park, Youngja H Park, Ki Yong Lee. Screening and identification of neuroprotective compounds from Scrophularia buergeriana using cell extraction coupled with LC–MS. Journal of Pharmaceutical and Biomedical Analysis 148, 355-360 (2018)
Jeong Hoon Pan, Yejin Lim, Jun Ho Kim, Wan Heo, Ki Yong Lee, HyeJi Shin, Jae Kyeom Kim, Jin Hyup Lee, Young Jun Kim. Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation. PLoS One. 12(11):e0188381 (2017)
Seonghu Park, Yeeun Park, Sang-Hyun Son, Kiho Lee, Yong Woo Jung, Ki Yong Lee, Young Ho Jeon, Youngjoo Byun. Synthesis and biological evaluation of peptide-derived TSLP inhibitors. Bioorganic & Medicinal Chemistry Letters 27, 4710–4713 (2017)
Ameeq Ul Mushtaq, Jeong Soon Park, Sung-Hun Bae, Hye-Yeon Kim, Kwon Joo Yeo, Eunha Hwang, Ki Yong Lee, Jun-Goo Jee, Hae-Kap Cheong, Young Ho Jeon. Ligand-Mediated Folding of the OmpA Periplasmic Domain from Acinetobacter baumannii. Biophysical Journal 112(10), 2089-2098 (2017)
Buyun Kim, Ki Yong Lee*, Byoungduck Park* Crocin Suppresses Constitutively Active STAT3 through Induction of Protein Tyrosine Phosphatase SHP-1. Journal of Cellular Biochemistry 118(10), 3290-3298 (2017) (*co-corresponding author)
Hongmok Kwon, JooYeon Han, Ki Yong Lee, Sang-Hyun Son, Youngjoo Byun. Recent advances of hepsin-targeted inhibitors. Current Medicinal Chemistry 24(21), 2294-2311 (2017)
Hyeji Shin, Yeeun Park, Ji Hoon Choi, Young Ho Jeon, Youngjoo Byun, Sang Hyun Sung*, Ki Yong Lee* Structure elucidation of a new triterpene from Rhus trichocarpa roots. Magnetic Resonance in Chemistry 55(8), 763-766 (2017) (*co-corresponding author)
Seung-min Yeon, Ju Hyung Lee, Daewon Kang, Hyuna Bae, Ki Yong Lee, Seohoon Jin, Jung Ryul Kim, Yong Woo Jung, Tae Won Park. Acytokine study of pediatric Tourette’s disorder without obsessive compulsive disorder.Psychiatry Research 247, 90-96 (2017)
Yun Hee Jeong, You-Chang Oh, Won-Kyung Cho, Hyeji Shin, Ki Yong Lee*, Jin Yeul Ma* Anti-inflammatory effects of Viola yedoensis and the application of cell extraction methods for investigating bioactive constituents in macrophages. BMC Complementary and Alternative Medicine 16(1), 180 (2016) (*co-corresponding author)
Kyung-Eon Oh, Hyeji Shin, Young Ho Jeon, Yang Hee Jo, Mi Kyeong Lee, Ken S. Lee, Byoungduck Park*, Ki Yong Lee* Optimization of pancreatic lipase inhibitory and antioxidant activities of Ilex paraguariensis by using response surface methodology. Archives of Pharmacal Research 39(7), 946-952 (2016) (*co-corresponding author)
Jeong Hoon Pan#,Ki Yong Lee#, Eui Seop Lee, Jin Hyup Lee, Young Jun Kim. Prunus mume Sieb. et Zucc. fruit ameliorates alcoholic liver injury in mice by inhibiting apoptosis and inflammation through oxidative stress. Journal of Functional Foods 25, 135-148 (2016) (#Both authors contributed equally to this work)
Ki Yong Lee*, Ji Hoon Choi, Hyeon Woo Kim, Xi-Tao Yan, Hyeji Shin, Young Ho Jeon, Sang Hyun Sung*. New alkyl phloroglucinol derivatives from Rhus trichocarpa roots and their cytotoxic effects on human gastric adenocarcinoma AGS cells. Planta Medica 82(7), 645-649 (2016) (*co-corresponding author)
Ki Yong Lee, Eun Ju Jeong, Sang Hyun Sung, Young Choong Kim. Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production. Records of Natural Products 10(1), 109-112 (2016)
Ji Yeon Jeong, Yang Hee Jo, Seon Beom Kim, Qing Liu, Jin Woo Lee, Eun Jin Mo, Ki Yong Lee, Bang Yeon Hwang, Mi Kyeong Lee. PancreaticlipaseinhibitoryconstituentsfromMorus alba leaves and optimization for extraction conditions. Bioorganic & Medicinal Chemistry Letters 25(11), 2269-74 (2015)
Ji-Hyun Park, Ki Yong Lee, Byoungduck Park, Jaewoo Yoon. Suppression of Th2-chemokines by crocin via blocking of ERK-MAPK/NF-κB/STAT1 signaling pathways in TNF[alpha]/IFN[gamma]-stimulated human epidermal keratinocytes. Experimental Dermatology 24(8):634-636 (2015)
Ji-Hyun Park, Jaewoo Yoon, Ki Yong Lee*, Byoungduck Park* Effects of geniposide on hepatocytes undergoing epithelial-mesenchymal transition in hepatic fibrosis by targeting TGFβ/Smad and ERK-MAPK signaling pathways. Biochimie 113, 26-34 (2015) (*co-corresponding author)
Eun Ju Jeong, Na-Hyun Kim, Jeong-Doo Heo, Ki Yong Lee, Jung-Rae Rho, Young Choong Kim, Sang Hyun Sung. Antifibrotic compounds from Liriodendron tulipifera attenuating HSC-T6 proliferation and TNF-α Production in RAW264.7 Cells. Biological & Pharmaceutical Bulletin 38(2), 228-234 (2015)